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Prebichol 10 Tablet is used for the treatment of primary biliary cirrhosis (also known as primary biliary cholangitis), an autoimmune disease that damages the bile ducts in the liver. This condition leads to a build-up of bile, causing liver damage. Prebichol 10 contains Obeticholic acid, which helps improve liver function by reducing bile production and accumulation in the liver, enhancing bile removal, and reducing inflammation, thus assisting in managing primary biliary cirrhosis.
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✅ Description:
Treatment Options for Biliary Cirrhosis:
Ursodeoxycholic Acid (UDCA): Commonly known as ursodiol (e.g., Urso, Actigall), this medication helps move bile through the liver, improving liver function and reducing scarring of liver tissue.
Obeticholic Acid (Ocaliva): When used in combination with ursodiol for about a year, obeticholic acid has been shown to improve liver function, especially in patients with primary biliary cirrhosis.
Fibrates (e.g., Tricor): These medications can reduce itching and inflammation of the liver when used alongside UDCA.
Other Medications:
- Colchicine (Colcrys) and Methotrexate (Trexall) can be used to treat the disease.
- Cholestyramine (Questran) and Rifampin (Rifadin) can help relieve itching.
- Opioid antagonists containing naloxone (e.g., Evzio, Bunavail) can also aid in managing itching.
- For fatigue, medications like Modafinil (Provigil) may be prescribed.
- Saliva substitutes and artificial tears can be used to treat dry mouth and dry eyes.
Liver Transplant: If medications do not provide sufficient relief or if liver function significantly declines, a liver transplant may be considered to slow liver damage and extend the patient's life.
Eligibility for Treatment:
Individuals showing symptoms like excessive itching, persistent fatigue, and long spells of dry mouth and dry eyes should consider getting diagnostic tests done.
Blood tests to examine cholesterol levels, liver enzyme levels, and antibodies can help confirm a diagnosis.
If the tests confirm primary biliary cirrhosis, the individual may be eligible for treatment. The treatment aims to manage symptoms, improve liver function, and slow down liver damage.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses
- Primary biliary cirrhosis
✔️ Possible Side Effects:
- Stomach pain
- Fatigue
- Dizziness
- Constipation
- Palpitations (irregular or rapid heartbeat)
- Thyroid irregularities
These side effects are typically mild and may resolve on their own. However, if they persist or worsen, consult your doctor.
✔️ Diet and Lifestyle Recommendations:
- Include a balanced diet with fruits and vegetables, as well as foods like bell peppers, citrus fruits, leafy greens, tomatoes, milk, fish, low-fat dairy, beans, nuts, lentils, tofu, and tempeh.
- Avoid high-fat, processed, or sugary foods, as well as tobacco and alcohol.
✔️ Usage Instructions:
- Take Prebichol 10 as prescribed by your doctor.
- The tablet should be swallowed whole with a glass of water—do not chew or crush it.
✔️ Overdose:
If you take more than the prescribed dose, symptoms of overdose may include yellowing of the skin or eyes, dark urine, loss of appetite, upper stomach pain, nausea, vomiting, or swelling around the stomach. If you suspect an overdose, seek immediate medical attention.
✔️ Obeticholic Acid (Ocaliva) Dosage and Management in Primary Biliary Cirrhosis (PBC):
Recommended Dosage Regimen:
- For PBC patients without cirrhosis or with compensated cirrhosis who:
- Have not achieved adequate biochemical response to an appropriate dosage of UDCA for at least 1 year, or are intolerant to UDCA:
- Start with 5 mg once daily for the first 3 months.
- After 3 months, if there has not been an adequate reduction in ALP (alkaline phosphatase) and/or total bilirubin and Obeticholic acid is tolerated, increase to a maximum dosage of 10 mg once daily.
- Have not achieved adequate biochemical response to an appropriate dosage of UDCA for at least 1 year, or are intolerant to UDCA:
Monitoring for Safety and Discontinuation:
- Regular monitoring during treatment is essential, particularly for:
- Biochemical response and tolerability of Obeticholic acid.
- Progression of PBC.
- Portal hypertension in patients with compensated cirrhosis, autoimmune hepatitis, alcoholic liver disease, or severe intercurrent illness.
- Signs of hepatic decompensation, such as elevated bilirubin levels, prothrombin time, or worsening ascites.
- Discontinue Obeticholic acid if:
- Laboratory or clinical evidence of hepatic decompensation develops.
- Signs of portal hypertension emerge.
- Clinically significant hepatic adverse reactions occur.
- Complete biliary obstruction occurs.
Management of Intolerable Pruritus:
- If pruritus (itching) becomes intolerable:
- Consider adding an antihistamine or bile acid-binding resin.
- Reduce Obeticholic acid dosage:
- 5 mg every other day for patients intolerant to 5 mg once daily.
- 5 mg once daily for patients intolerant to 10 mg once daily.
- Temporarily interrupt dosing for up to 2 weeks and then restart at a lower dose.
- If symptoms persist despite adjustments, consider discontinuing Obeticholic acid treatment.
✔️ Drug Interactions:
- Severe interaction with Tizanidine.
- Moderate interaction with caffeine-containing foods or drinks.
- It may interact with medications like theophylline, warfarin, cholestryamine, colestipol, and colesevelam.
✔️ Contraindications:
- Child-Pugh Class B or C: Obeticholic acid is contraindicated in patients with severe liver impairment (Child-Pugh Class B or C), especially those who have had a prior decompensation event or have compensated cirrhosis with evidence of portal hypertension (e.g., ascites, gastroesophageal varices, persistent thrombocytopenia).
✔️ Important Warnings:
- Do not take Prebichol 10 if you are allergic to any of its components or if you have a blockage in your biliary tract (liver, bile ducts, or gallbladder).
- If you experience unbearable itching, consult your doctor.
- Prebichol 10 is not recommended during pregnancy or breastfeeding unless necessary. Discuss the risks with your doctor.
- This medication is not recommended for children and adolescents.
- Prebichol 10 may cause dizziness, so use caution when driving.
- Seek immediate medical help if you notice yellowing of the skin or eyes, black or tarry stools, dark urine, coughing up or vomiting blood, confusion, slurred speech, mood swings, anxiety, or swelling around the stomach.
✔️ Storage:
- Store in a cool, dry place, away from sunlight.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
